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Vitamin K2: ideally 180 to 360 micrograms per day.

Vitamin D3: ideally 4,000 to 5,000 IU per day.

Resveratrol: 1g per day, in the morning.

Nicotinamide mononucleotide (NMN): 1g per day, in the morning.

Sinclair’s supplement and longevity drug stack likely looks as follows: We don’t know if he still takes these supplements or whether he takes additional supplements that are not included on this list.įor example, in his book Lifespan, he mentions on page 304 that he takes NMN and resveratrol every morning, often mixed in his yogurt.īased on multiple, recent interviews and his book, Dr. We compiled this list from interviews and books in which Dr. Sinclair has made a point to not promote or endorse any supplement products. You may have come across his published, New York Times best-selling book on aging, Lifespan: Why We Age – And Why We Don’t Have To, going deeper into those subjects (you can find our favorite longevity books here).

David Sinclair’s main research interest is the epigenetics of aging, with a focus on epigenetic reprogramming of aging (e.g., reversing aging via Yamanaka factors), NAD+ metabolism and sirtuins, and NAD+ precursors like NR and NMN. Vitamin D3 and K2 work together to benefit bone health, cardiovascular support, and healthy immune function.* Maintaining an optimal level of vitamin D throughout all stages of life helps maintain strong bones and healthy immune function.* Adding vitamin K2 helps move calcium to the bones to protect soft tissues, such as the arteries and kidneys, from calcification.* Combining vitamins D3 and K2 provides greater benefit together than each offers separately.David Sinclair is a professor at Harvard University who has been studying aging for the better part of his academic career.ĭr.